How can thermal gradients drive Darwinian Evolution? Can we host replication and selection on the molecular level in a single chamber? We experimentally probe disequilibrium scenarios of early evolution. This project is funded with an ERC Starting Grant.
We use a thermal field to quantify the affinity of biomolecule binding. A wide range of concentrations and molecule sizes can be probed. See our Biotech Startup NanoTemper
How fast are reactions inside living cells? We invented an optical Lock-in method is used to image fast kinetics in living cells with optical resolution.
We showed that a moving laser can accumulate short DNA by combining thermophoresis and light driven microflow. The result is a molecule trap going far beyond optical trapping.
We invented a way to use a warm laser spot to move water with optical resolution (also in ice). This is the basis for light driven microfluidics. Fluids can be moved without mechanical contact.
We used a local equilibrium model to predict thermophoresis quantitatively for the first time. The model was applied equally well to polystyrene beads and DNA of various length.